SHIP1 and Lyn Kinase Negatively Regulate Integrin αIIbβ3 Signaling in Platelets

Neutrophil Integrin Signaling The Lyn Tyrosine Kinase Negatively Regulates

Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase

IgG immune complexes contribute to the etiology and pathogenesis of numerous autoimmune disorders, including heparin-induced thrombocytopenia, systemic lupus erythematosus, rheumatoid- and collagen-induced arthritis, and chronic glomerulonephritis. Patients suffering from immune complex-related disorders are known to be susceptible to platelet-mediated thrombotic events. Though the role of the ...

G12/13 Signaling Pathways Substitute for Integrin αIIbβ3-Signaling for Thromboxane Generation in Platelets

BACKGROUND We have previously shown that ADP-induced TXA(2) generation requires signaling from αIIbβ3 integrin in platelets. Here we observed that, unlike ADP, protease-activated receptor (PAR)-mediated TXA(2) generation occurs independently of αIIbβ3. PAR agonists, but not ADP, activate G(12/13) signaling pathways. Hence, we evaluated the role of these pathways in TXA(2) generation. PRINCIPA...

IDENTIFICATION OF A UNIQUE CO-OPERATIVE PI 3-KINASE SIGNALING MECHANISM REGULATING INTEGRIN αIIbβ3 ADHESIVE FUNCTION IN PLATELETS

IDENTIFICATION OF A UNIQUE CO-OPERATIVE PI 3-KINASE SIGNALING MECHANISM REGULATING INTEGRIN αIIbβ3 ADHESIVE FUNCTION IN PLATELETS Simone M. Schoenwaelder, Akiko Ono, Sharelle Sturgeon, * Mei Chan, * Pierre Mangin, Mhairi J Maxwell, Shannon Turnbull, Megha Mulchandani, Karen Anderson, Gilles Kauffenstein, Gordon W. Rewcastle, Jackie Kendall, ‡ Christian Gachet, Hatem H Salem and Shaun P Jackson ...

JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets.

Mounting evidence suggests that agonist-initiated signaling in platelets is closely regulated to avoid excessive responses to injury. A variety of physiologic agonists induce a cascade of signaling events termed as inside-out signaling that culminate in exposure of high-affinity binding sites on integrin α(IIb)β(3). Once platelet activation has occurred, integrin α(IIb)β(3) stabilizes thrombus ...